Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells

Mouse Cd1d Phosphatidylinositol Mannoside Binding to Structural Characterization of Mycobacterial

CD1d-Restricted Natural Killer T Cells

Natural killer T (NKT) cells that express the semi-invariant T-cell receptor are innate-like lymphocytes whose functions are controlled by self and foreign glycolipid ligands. Such ligands are presented by the antigen-presenting, MHC class I-like molecule CD1d, which belongs to a family of lipid antigen-presenting molecules collectively called CD1. Activation of NKT cells in vivo results in rap...

CD1d-Restricted Antigen Presentation by Vg9Vd2-T Cells Requires Trogocytosis

CD1d-restricted invariant natural killer T cells (iNKT) constitute an important immunoregulatory T-cell subset that can be activated by the synthetic glycolipid a-galactosylceramide (a-GalCer) and play a dominant role in antitumor immunity. Clinical trials with a-GalCer–pulsed monocyte-derived dendritic cells (moDC) have shown anecdotal antitumor activity in advanced cancer. It was reported tha...

CD1d-restricted antigen presentation by Vγ9Vδ2-T cells requires trogocytosis.

CD1d-restricted invariant natural killer T cells (iNKT) constitute an important immunoregulatory T-cell subset that can be activated by the synthetic glycolipid α-galactosylceramide (α-GalCer) and play a dominant role in antitumor immunity. Clinical trials with α-GalCer-pulsed monocyte-derived dendritic cells (moDC) have shown anecdotal antitumor activity in advanced cancer. It was reported tha...

Mycobacterial Phosphatidylinositol Mannoside 6 (PIM6) Up-Regulates TCR-Triggered HIV-1 Replication in CD4+ T Cells

Tuberculosis (TB) is the leading cause of mortality among those infected with human immunodeficiency virus (HIV-1) worldwide. HIV-1 load and heterogeneity are increased both locally and systemically in active TB. Mycobacterium tuberculosis (MTB) infection supports HIV-1 replication through dysregulation of host cytokines, chemokines, and their receptors. However the possibility that mycobacteri...